MD Simulation of Protein-Ligand Interaction: Formation and Dissociation of an Insulin-Phenol Complex
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چکیده
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15 صفحه اولThe Importance of α-CT and Salt bridges in the Formation of Insulin and its Receptor Complex by Computational Simulation
Insulin hormone is an important part of the endocrine system. It contains two polypeptide chains and plays a pivotal role in regulating carbohydrate metabolism. Insulin receptors (IR) located on cell surface interacts with insulin to control the intake of glucose. Although several studies have tried to clarify the interaction between insulin and its receptor, the mechanism of this interaction r...
متن کاملThe Importance of α-CT and Salt bridges in the Formation of Insulin and its Receptor Complex by Computational Simulation
Insulin hormone is an important part of the endocrine system. It contains two polypeptide chains and plays a pivotal role in regulating carbohydrate metabolism. Insulin receptors (IR) located on cell surface interacts with insulin to control the intake of glucose. Although several studies have tried to clarify the interaction between insulin and its receptor, the mechanism of this interaction r...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2003
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(03)74962-5